Maurizio Sarri is likely to make wholesale changes to the side that beat West Ham 2-0 on Monday, as Chelsea look to manage a jam-packed fixture list.
Willian, Pedro and Olivier Giroud are likely to earn a recall, while Andreas Christensen and Marcos Alonso could replace Antonio Rudiger and Emerson Palmieri..
Willy Caballero may also be granted a start in place of Kepa Arrizabalaga, while Ross Barkley should come in for Ruben Loftus-Cheek.
Slavia Prague will be without Tomas Soucek after the midfielder picked up his third Europa League yellow card of the season against Sevilla.
— Chelsea FC (@ChelseaFC) April 11, 2019
Chelsea team to play Slavia Prague: Arrizabalaga, Azpilicueta, Christensen, Rudiger, Alonso, Kovacic, Jorginho, Barkley, Pedro, Giroud, Willian
Subs: Caballero, Zappacosta, Luiz, Kante, Loftus-Cheek, Hazard, Higuain.