Anthony Martial and Romelu Lukaku are expected to be fit for the trip to Molineux.
Martial scored in the 2-1 win over Watford over the weekend but later limped out of the fixture while fellow forward Lukaku was an unused substitute.
Ole Gunnar Solskjaer will be without injured quartet Alexis Sanchez, Antonio Valencia, Eric Bailly and Matteo Darmian.
MAN UTD TEAM NEWS
Starting XI: De Gea, Young, Smalling, Lindelof, Shaw, Dalot, McTominay, Pogba, Fred, Lingard, Lukaku.
Subs: Romero, Jones, Rojo, Matic, Pereira, Mata, Martial.
WOLVES TEAM NEWS
Starting XI: Patricio, Bennett, Coady, Boly, Doherty, Dendoncker, Neves, Moutinho, Vinagre, Jota, Jimenez.
Subs: Ruddy, Saiss, Jonny, Gibbs-White, Traore, Costa, Cavaleiro.