Seven changes in total by Ole Gunnar Solskjaer following the 1-1 draw with Everton, but it’s a strong statement on intent from the Norwegian.
Harry Maguire, Luke Shaw, Marcus Rashford and Anthony Martial are the only players to retain their places as those on the fringes of the squad are recalled.
Mason Greenwood will look to continue his fine goalscoring form from the start this evening, while Nemanja Matic, Juan Mata and Andreas Pereira return.
MAN UTD TEAM NEWS
Starting XI: Romero, Young, Tuanzebe, Maguire, Shaw, Matic, Pereira, Greenwood, Mata, Rashford, Martial.
Subs: Grant, Jones, Williams, Garner, Lingard, McTominay, Chong.
COLCHESTER TEAM NEWS
Starting XI: Gerken, Jackson, Bramall, Lapslie, Prosser, Pell, Norris, Comley, Harriott, Eastman, Nouble.
Subs: Ross, Sowunmi, Brown, Clampin, Stevenson, Gambin, Poku.